Microfluidic-based separations benefit
from the ability to control fluids with high precision and the reduction of cost, total analyisis times, and sample and reagent consumption. Electrokinetically driven separations on microfluidic devices have generated efficiencies per unit length similar to or exceeding that of conventional capillary systems. We are currently developing microfluidic devices with various geometries optimized for one- and two-dimensional separations that will shorten analysis times and improve the peak capacity, accuracy, and reproducibly compared to conventional techniques. We are also using this technology to study the onset and progression of diseases such as cancer.